Achalasia is an uncommon swallowing disorder that affects about 1 in every 100,000 people.
diagnosed between the ages of 25 and 60 years.
Loss of ganglion cells within the esophageal myenteric nerve plexus. →leads to impaired deglutitive LES relaxation and absent peristalsis
*Increasing evidence suggests that the ultimate cause of ganglion cell degeneration in achalasia is an autoimmune process attributable to a latent infection with human herpes simplex virus 1 combined with genetic susceptibility.