2. Clinical Findings
3. Medical Management
4. Case Study
5. Nursing Management
TLS occurs from the rapid release of intracellular components during cell death.
When cancer cells are destroyed by chemotherapy or radiation, they spill their intracellular components into the bloodstream, causing an influx of potassium, phosphorus, and nucleic acid
Hyperuricemia occurs when the liver converts nucleic acids into uric acid.
hypocalcemia develops as serum calcium binds to elevated amounts of phosphorus within the bloodstream.
Ⅱ. Treatment Measures
Hyperkalemia : sodium polystyrene sulfonate, diuretics, IV glucose and insulin infusions,
IV calcium gluconate, dialysis
Hyperphosphatemia and hypocalcemia
: IV 10% calcium gluconate,
oral phosphate binders,
dietary restriction of phosphorus intake,