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쿠싱증후군의 증상 및 신체검진과 진단법

저작시기 2012.09 |등록일 2013.04.06 한글파일한글 (hwp) | 4페이지 | 가격 1,000원

소개글

내분비내과 A받은 레포트입니다.

목차

A. Definition of Cushing`s synd.
B. Pathophysiology of Cusing`s synd.
C. Clinical menifestation
D. 진단
E. 감별진단

본문내용

A. Definition of Cushing`s synd.
Cushing`s syndrome reflects a constellation of clinical features that result from chronic exposure to excess glucocorticoids of any etiology. The disorder can be ➀ ACTH-dependent(e.g.,pituitary corticotropeadenoma, ectopicsecretion of ACTH by nonpituitary tumor) or ➁ ACTH-independent (e.g., adrenocorticaladenoma, adrenocorticalcarcinoma, nodularadrenalhyperplasia), as well as ➂ iatrogenic (e.g.,administration of exogenous glucocorticoids to treat various inflammatory conditions).
Iatrogenic steroid투여가 전체적으로 Cushing’s syndrome의 m/c원인이다. Cushing’s disease는 pituitary ACTH overproduction에 의한 질환을 의미한다.

B. Pathophysiology of Cusing`s synd.
1. mineralocorticoid activation by cortisol
2. RAA activation

3. cathecolamine, vasopressin, AT II과잉
4. Suppresion of NO synthase, prostacyclin, Kinin-kalikrein system
5. insulin resistance

-> Volume expansion, increase in cardiac output, increase in pheripheral and renal resistance -> HTN

참고 자료

Fauci, Anthony S., et al. Harrisons Principles of Internal Medicine. 18th ed. United States: McGraw-Hill Professional, 2012
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