AbstractOsteoporosis is consequence of an unbalanced bone remodeling process
decrease in bone density, alterations in bone microarchitecture, and ultimately Fractures.
predominantly a disease of aging, affecting particularly postmenopausal women, but also older men
bisphosphonates, denosumab, calcitonin, estrogens or selective estrogen receptor modulators
they lead to a low turnover state -> decrease in bone-remodeling activity
alternative class of osteoporosis drugs -> bone anabolics
PTH : the only anabolic drug currently on the market
canonical Wnt signaling : through inhibition of the endogenous inhibitors (sclerostin and dickkopf1)