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저작시기 2011.11 |등록일 2012.05.05 파워포인트파일MS 파워포인트 (ppt) | 74페이지 | 가격 3,000원

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본문내용

Stimuli-sensitive polymer의 특성
Stimuli-sensitive property
Behavior : intra or intermolecular interaction of polymer chain
Driving forces : van der Waals interaction, hydrophobic interaction, hydrogen bonding, electrostatic interaction
Stimuli-sensitive hydrogel
Crosslinking
Physical : temperature, ionic strength, solvent, UV/VIS light, electric field, magnetic field
Chemical : pH, specific ions, chemical species
Biological : enzyme, glucose, antigen, other biomolecules

Thermosensitive polymer
Poly(N-isopropyl acrylamide)
LCST : 32℃
Hydrophilic : acrylic acid, N,N-diethylaminoethyl methacrylate, acrylamide - LCST 증가
Hydrophobic : butyl methacrylate ? LCST 감소
Poloxamer : LCST 10~100℃
PLA or PLGA-PEO block or graft copolymer : biodegradable

Thermosensitive polymer
Self-regulated drug delivery
Injectable delivery
Tissue engineering
Targeted delivery
Gene delivery
Thermo-sensitive surfaces

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