GI hemorrhage is the m/c serious bleeding complication from the use of long-term antiplatelet therapy.
Randomized, controlled trials have shown that
PPI reduce the rate of recurrent GI bleeding in high-risk patients receiving aspirin.
however, Observational studies have suggested that
may be an interaction between clopidogrel and PPIs
however, A number of other observational studies,
did not show an interaction between clopidogrel and PPIs