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Epidermal_cell_kinetics,_Epidermal_Differentiation,_and

저작시기 2012.01 |등록일 2012.01.16 파워포인트파일MS 파워포인트 (pptx) | 17페이지 | 가격 630원 (30%↓) 900원

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epidermal cell kinetics 에 관한 PPT 입니다. keratinocyte 에 관한 자세한 내용이 포함되어 있습니다.

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본문내용

Epidermal cell kinetics, Epidermal Differentiation, and Keratinization

Two population of stem cells
Epidermal keratinocyte→cornified cells
Hair follicle → hair shaft (bipotential)
Slow-cycling epidermal stem cells
Tritiated thymidine labeling, retention up to 14 months
Bulge region of the hair follicle
Above the dermal papillae in nonacral skin
deep portion of epidermal rete ridges on acral skin
Stem cells

Transient amplifying cells
: limited capacity for self-renewal
Epidermal proliferative unit (1 stem cell ? 9 transient amplifying cells)


Isolation of stem cells
Keratin 19/ high telomerase activity (X)
Keratin-15, c-Myc, a non-cadherin-associated ß-catenin, p63
Recently, Integrins esp. ß1- integrin rich keratinocytes : But, not specific
Basal keratinocyte ( 90% transient amplifying cells, 6.5% differentiated cells, 3.5% stem cell)
depend on ß1 integrin signaling, through MAPK pathway, non-cadherin-associated ß-catenin
Stem cells

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