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OR MDR method 발표자료

저작시기 2006.05 |등록일 2010.01.08 파워포인트파일MS 파워포인트 (ppt) | 30페이지 | 가격 2,900원

소개글

OR MDR method for detecting gene-gene interaction

목차

MDR
- Purpose & Method
- Algorithm
- Example
- Advantages
- Disadvantages
OR MDR
- Purpose & Method
- Algorithm
- Example
- Advantages
- Further Study

References

본문내용

Multifactor Dimensionality Reduction

Ritchie et al. (2001) Multifactor-Dimensionality Reduction Reveals High-Order Interactions among Estrogen-Metabolism Genes in Sporadic Breast Cancer, Am. J. Hum. Genet., 69, 138-147.

(1) Purpose & Method
Purpose : Improvement of the identification of polymorphism combinations associated with disease risk

Method : Reduce the dimensionality of multilocus information

(2) Algorithm
Step 1 : Divide the data set into training set and test set (For Cross-validation)

Step 2 : Select n genetic, environmental factors from all factors.

Step 3 : Represent all possible multifactor classes of n factors in n-dim. space

참고 자료

Chung, Yujin et al. (2007), Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions, Bioinformatics, 23, 71-76

Hahn, L. W. et al. (2003), Multifactor dimensionality reduction software for detecting gene–gene and gene–environment interactions, Bioinformatics, 19, 376–382.

Ritchie, M. D. et al. (2001), Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer, Am. J. Hum. Genet., 69, 138–147.
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