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specific disease entities

저작시기 2008.03 |등록일 2009.05.08 파워포인트파일MS 파워포인트 (ppt) | 13페이지 | 가격 500원

소개글

sprue 와 흡수장애등 해리슨 리뷰입니다.

목차

CELIAC SPRUE
TROPICAL SPRUE
SHORT BOWEL SYNDROME
WHIPPLE’S DISEASE

본문내용

CELIAC SPRUE

Caucasians, especially European
Protean manifestations
diarrhea, steatorrhea, Wt loss, anemia and metabolic bone disease
no GI symptoms but with evidence of the depletion of a single nutrient
Etiology
environmental factor : gliadin, a component of gluten
immunologic component
serum Ab : IgA antigliadin, IgA antiendomysial, IgA anti-tTG Ab
Response to prednisolone , continues to eat gluten
Genetic factor(s)
10% in firstdegree relatives
HLA-DQ2 allele : about 95%

The hallmark of celiac sprue is the presence of an abnormal smallintestinal
biopsy (Fig. 275-4) and the response of both symptoms—
evidence of malabsorption and the histopathologic
changes on the small-intestinal biopsy—
to the elimination of gluten from the
diet. The histopathologic changes have a proximal
to distal intestinal distribution of severity,
which probably reflects the exposure of the intestinal
mucosa to varied amounts of dietary
gluten; the degree of symptoms is often related
to the extent of these histopathologic changes

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