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[의학]effect of hyaluronic acid on peripheral nerve scarring and regeneration in rat

저작시기 2007.03 |등록일 2007.03.20 파워포인트파일MS 파워포인트 (ppt) | 15페이지 | 가격 2,000원

소개글

PNS의 신경 수술후 생기는 scar formation을 억제 시키고 정상적으로 재생 되도록 촉진 시키는 히알루론산의 역할을 살펴 보기위한 논문

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본문내용

Peripheral nerve surgery
Several factors are responsible for incomplete recovery

Scar formation
inevitable sequel of peripheral nerve surgery
mechanical barrier to axonal regeneration
tethering of nerves to adjacent tissue
preventing nerve mobility
causing traction injury
Reducing scar formation improve the outcome after peripheral nerve repair

Reducing scar formation
pharmacologic agents
Aprotinin (antibody to TGFb)
Human amniotic fluid
positive effects in experimental study  not apply in clinical field
wrapping of nerves with vein, muscle, fat  inconsistent
Objective of this study
Investigate the effects of HA (1000KDa) on peripheral nerve scarring and regeneration after nerve surgery

Hyaluronic acid (HA)
reduce the extent of scar formation
inhibiting lymphocyte migration proliferation chemotaxis
granulocyte pagocytosis and degranulation
macrophage motility

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