Oncogene의 기능 및 oncogene casecade에 중점을 맞춘 자료
1.Oncogenes are often targeted by chemical carcinogens
2.Function of oncoprotein
3.Growth factors and activation of c-Src
4.Subversion of Apoptosis pathways by Oncogene in Hematopoitic cells
5.Subversion of cell cycle checkpoints by Oncogene
Oncogenes are often targeted by chemical carcinogens
chemical carcinogen은 다양하고 폭 넓은 range의 structure를 가짐.
Do not act directly but modification by cytochrome p450 proteins.
Two type의 chemical carcinogen존재
Interact with wide variety of cellular components; DNA, RNA, Protein
Most important of these interaction is with DNA
DNA transfection using NIH/3T3 cell을 이용한 실험으로 증명
Protooncogenes might be the crucial targets of the chemical carcinogens.
A number of chemical carcinogens were shown to act Protooncogenes, by converting them into dominant transforming genes.