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[재료공학]Force Spectroscopy

저작시기 2005.05 |등록일 2006.04.27 파워포인트파일MS 파워포인트 (ppt) | 19페이지 | 가격 2,000원

소개글

사이언스나 네이쳐에 실린 Force spectroscopy에 대한 논문을
소개하는 전문 자료입니다
발표를 위해 만든 자료입니다.

목차

overview
Dynamic Force Spectroscopy of Specific Biomolecular Bonds
Force Spectroscopy & Force Microscopy of Cell Membranes
Protein (Un-)folding
DNA Mechanics
DNA-protein Interaction
Molecular Motors
Methods
AFM Cantilevers
Microneedles
Optical Tweezers
Outlook

본문내용

Force ⇒ important functional & structural parameter
At molecular level
Meacurement of mechanical forces
⇒ detailed insights into the function and structure
of many biological systems
ex) Cell adhesion, protein folding pathways, DNA mechanics
Today, a number of the techniques differing in force- &
dynamical ranges are available
Unbinding and desorption processes
Resulting forces ⇒ classified as “intermolecular”
I. the rupture of covalent chemical bonds
II. the unbinding of different kinds of intermolecular
aggregates based on noncovalent binding
interactions
ex) ligand-receptor pairs, coordination complexes,
hydrogen- bonded systems, ion pairs, or hydro-
phobically assembled structures.
The natural off-rate of the binding interactions <
maximum force loading rates applicable in the experiment
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