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Seizures and Epilepsy
Epidemiology ofSeizures and Epilepsy
Cellular Mechanisms ofSeizure Generation
Mechanisms of Generating Hyperexcitable Networks
CLASSIFICATION OF EPILEPTIC SEIZURES
Etiology of Seizuresand Epilepsy
Evaluation of a First Seizure
Medical Treatment ofFirst Seizure
Choosing Antiepileptic Drugs
INFORMATION ON COMMON ANTIEPILEPTIC DRUGS
Antiepileptic Drug Monotherapy
Antiepileptic Drug Interactions
Therapeutic Range” of AEDSerum Concentrations
Non-Drug Treatment/Lifestyle Modifications
Vagal Nerve Stimulator
Patient Selection for Surgery:Criteria
Status Epilepticus TX
Pregnancy and Epilepsy
Most pregnancies in epileptic mothers produce normal children
Fetal anomalies (up to 10% of pregnancies) are multifactorial
Consequences of the mother’s underlying diseases
Consequence of maternal seizures during pregnancy
All antiepileptic drugs carry teratogenic risks
Pregnancy and Epilepsy (cont.)
Effects on pregnancy on epilepsy
Risk of increased seizures (low if compliance maintained, doses adjusted upward to maintain free levels)
Risk of seizures during delivery (impaired absorption, sleep deprivation, exhaustion)